Genetic analysis of protein kinase B (AKT) in Drosophila
نویسندگان
چکیده
منابع مشابه
Genetic analysis of protein kinase B (AKT) in Drosophila
The decision between survival and death is an important aspect of cellular regulation during development and malignancy. Central to this regulation is the process of apoptosis, which is conserved in multicellular organisms [1]. A variety of signalling cascades have been implicated in modulation of apoptosis, including the phosphatidylinositol (Pl) 3-kinase pathway. Activation of Pl 3-kinase is ...
متن کاملPhysiological functions of protein kinase B/Akt.
The genetic manipulation of mice has become an essential and elegant method for studying the function of proteins in physiology, and for testing the veracity of information obtained from cell culture experiments. During the past few years, a variety of transgenic and knockout mouse models of PKB (protein kinase B)/Akt have been generated and investigated. In this paper, we focus on the phenotyp...
متن کاملProtein kinase B/Akt at a glance.
Among the signalling proteins that respond to a large variety of signals, protein kinase B (PKB, also known as Akt) appears to be a central player in regulation of metabolism, cell survival, motility, transcription and cell-cycle progression. Conserved from primitive metazoans to humans, PKB belongs to the AGC subfamily of the protein kinase superfamily, which consists of 518 members in humans ...
متن کاملThe effect of high-intensity interval training on the expression of protein kinase B (Akt gene) in the left ventricle of male rats with type 2 diabetes
Introduction: The term diabetes heart in diabetic patients includes pathologic left ventricular hypertrophy. Stimulation of the signaling and molecular pathways of cardiac myocardial remodeling through exercise in this regard can be considered as a therapeutic strategy for physiological development of the left ventricle. In the present study, the effect of 8 weeks of high intensity interval tra...
متن کاملRoles of protein kinase B/Akt in lung cancer.
Lung cancer is the leading cause of cancer-related death worldwide and has frequently been associated with over-activated protein kinase B (PKB)/Akt. Akt is a serine/threonine protein kinase that plays an important role in cell growth, proliferation, and survival. Many lines of evidence point to the contribution of deregulated Akt in development or progression of lung cancer. In addition, recen...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Current Biology
سال: 1998
ISSN: 0960-9822
DOI: 10.1016/s0960-9822(98)70231-3